Multidrug Sensitivity in Herding Breeds: MDR1 Gene Mutation

MDR1 Gene Mutation: The MDR1 gene encodes P-glycoprotein, a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain), as well as enhancing the excretion of many drugs used in dogs. Some dogs, particularly herding breeds, have a mutation in the MDR1 gene, leaving them defective in […]